BS8366

antibody from Bioworld Technology, Inc
Targeting: PPM1A MGC9201, PP2CA, PP2Calpha
Provider product page for BS8366
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8366 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PPM1A polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PPM1A.
Description
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/ threonine protein phosphatases. Protein phosphatase 2Ca (PP2Ca) has broad specificity. It dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase-kinases while also inhibiting the activation of p38 and JNK kinase cascades, induced by environmental stresses. PP2Ca also induces the expression of endogenous p53 and the p53-responsive gene p21, leading to cell cycle arrest and apoptosis. The PP2Ca protein, which contains an active site containing a dinuclear metal ion center, shows highest expression in epithelial cells, as well as in the digestive tract, lung, kidney, breast, prostate, endocrine glands and brain.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPM1A protein structure - BS8366 shown in red.