TICAM1

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

Description

Toll like receptor adaptor molecule 1

Tissue specificity

Tissue enhanced (esophagus)

Subcell location

Nucleoplasm, Nucleoli, Plasma membrane

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (4815932 - 4831712)

Ensembl ID

ENSG00000127666  (ver. 103.38)

Orthologs

Mouse Ticam1: ENSMUSG00000047123

UniProt

Q8IUC6

neXtProt

NX_Q8IUC6

Human splice variants
Mouse splice variants

Protein structure