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Cell line expression
Protein structure
DUOX1
Dual oxidase 1LNOX1, NOXEF1, THOX1
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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| Novus Biologicals |  NB100-93521 |
3 references | Polyclonal |
WB
EL
IHC
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| GeneTex | GTX119160 |
1 references | Polyclonal |
WB
IHC
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| Biorbyt | orb869450 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN449366 |
3 references | Polyclonal |
WB
EL
IHC
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| Proteintech Group | 67226-1-Ig |
1 references | Monoclonal |
WB
EL
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