Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
RBL1
RB transcriptional corepressor like 1cp107, p107, PRB1
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
| Proteintech Group |  13354-1-AP |
11 references | Polyclonal |
WB
EL
IP
|
|
| Atlas Antibodies | HPA054962 |
Polyclonal |
WB
ICC
IHC
|
||
| Novus Biologicals | NBP2-33735 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Abnova Corporation | PAB4915 |
3 references | Polyclonal |
WB
EL
IHC
|
|
| LSBio | LS-C822170 |
Polyclonal |
EL
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider