GHRH

This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Description

Growth hormone releasing hormone

Tissue specificity

Tissue enriched (brain)

Predicted location

Secreted in other tissues

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

20 (37251086 - 37261814)

Ensembl ID

ENSG00000118702  (ver. 103.38)

Orthologs

Mouse Ghrh: ENSMUSG00000027643

UniProt

P01286

neXtProt

NX_P01286

Human splice variants
Mouse splice variants

Protein structure