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Cell line expression
Protein structure
SLC12A1
Solute carrier family 12 member 1NKCC2
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven. [provided by RefSeq, May 2010]
Top validated antibodies |
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| Proteintech Group |  18970-1-AP |
12 references | Polyclonal |
WB
EL
ICC
IHC
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| NovoPro Bioscience Inc. | 113195 |
Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | NBP1-80993 |
1 references | Polyclonal |
WB
ICC
IHC
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| Everest Biotech | EB09143 |
Polyclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX47166 |
2 references | Polyclonal |
WB
IHC
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