MPP6

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]). [supplied by OMIM, Mar 2008]

Description

Membrane palmitoylated protein 6

Tissue specificity

Tissue enhanced (brain, testis)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (24573268 - 24694193)

Ensembl ID

ENSG00000105926  (ver. 103.38)

Orthologs

Mouse Mpp6: ENSMUSG00000038388

UniProt

Q9NZW5

neXtProt

NX_Q9NZW5

Human splice variants
Mouse splice variants

Protein structure