HOXA13

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]

Description

Homeobox A13

Tissue specificity

Tissue enhanced (cervix, placenta, prostate, seminal vesicle)

Subcell location

Nucleoplasm, Mitotic chromosome, Intermediate filaments

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

7 (27193503 - 27200091)

Ensembl ID

ENSG00000106031  (ver. 103.38)

Orthologs

Mouse Hoxa13: ENSMUSG00000038203

UniProt

P31271

neXtProt

NX_P31271

Human splice variants
Mouse splice variants

Protein structure