CHMP4C

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). [supplied by OMIM, Mar 2008]

Description

Charged multivesicular body protein 4C

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Microtubules, Cytokinetic bridge

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (81732448 - 81759515)

Ensembl ID

ENSG00000164695  (ver. 103.38)

Orthologs

Mouse Chmp4c: ENSMUSG00000027536

UniProt

Q96CF2

neXtProt

NX_Q96CF2

Human splice variants
Mouse splice variants

Protein structure