PDIA6

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Description

Protein disulfide isomerase family A member 6

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (10783391 - 10837977)

Ensembl ID

ENSG00000143870  (ver. 103.38)

Orthologs

Mouse Pdia6: ENSMUSG00000020571

UniProt

Q15084

neXtProt

NX_Q15084

Human splice variants
Mouse splice variants

Protein structure