APR05847G

antibody from Leading Biology

Targeting: ERN2 IRE1b

Western blot (Recommended by provider)

Antibody Data

Product number

APR05847G

Provider

Leading Biology

Product name

ERN2 Antibody (C-term)

Antibody type

Polyclonal

Description

ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.