ARNTL2

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Description

Aryl hydrocarbon receptor nuclear translocator like 2

Tissue specificity

Tissue enhanced (esophagus, lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

12 (27332854 - 27425289)

Ensembl ID

ENSG00000029153  (ver. 103.38)

Orthologs

Mouse Arntl2: ENSMUSG00000040187

UniProt

Q8WYA1

neXtProt

NX_Q8WYA1

Human splice variants
Mouse splice variants

Protein structure