TMPRSS11D

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

Description

Transmembrane serine protease 11D

Tissue specificity

Group enriched (cervix, esophagus, lymphoid tissue, salivary gland, vagina)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

4 (67820876 - 67884002)

Ensembl ID

ENSG00000153802  (ver. 103.38)

Orthologs

Mouse Tmprss11d: ENSMUSG00000061259

UniProt

O60235

neXtProt

NX_O60235

Human splice variants
Mouse splice variants

Protein structure