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Protein structure
IL18
Interleukin 18IGIF, IL-18, IL-1g, IL1F4
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Proteintech Group |  10663-1-AP |
79 references | Polyclonal |
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EL
ICC
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| Invitrogen Antibodies | PA5-79479 |
4 references | Polyclonal |
WB
ICC
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OA
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| Atlas Antibodies | HPA003980 |
2 references | Polyclonal |
WB
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| R&D Systems | D044-3 |
20 references | Monoclonal |
EL
IP
BN
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| NSJ Bioreagents | F52493 |
Polyclonal |
WB
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