Tissue expression
Cell line expression
Protein structure
IL18
Interleukin 18IGIF, IL-18, IL-1g, IL1F4
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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Proteintech Group | ![]() |
250 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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Atlas Antibodies | ![]() |
2 references | Polyclonal |
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R&D Systems | ![]() |
20 references | Monoclonal |
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NSJ Bioreagents | ![]() |
Polyclonal |
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