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Protein structure
MCM7
Minichromosome maintenance complex component 7CDC47, MCM2, PPP1R104
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  11225-1-AP |
6 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Novus Biologicals | H00004176-M01 |
4 references | Monoclonal |
WB
EL
ICC
IHC
PLA
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| Abnova Corporation | H00004176-M01 |
3 references | Monoclonal |
WB
EL
ICC
IHC
PLA
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| GeneTex | GTX110278 |
1 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | 11225-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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