S1PR5

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors. [supplied by OMIM, Mar 2008]

Description

Sphingosine-1-phosphate receptor 5

Tissue specificity

Tissue enhanced (brain)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (10512742 - 10517931)

Ensembl ID

ENSG00000180739  (ver. 103.38)

Orthologs

Mouse S1pr5: ENSMUSG00000045087

UniProt

Q9H228

neXtProt

NX_Q9H228

Human splice variants
Mouse splice variants

Protein structure