TNFRSF25

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

Description

TNF receptor superfamily member 25

Tissue specificity

Tissue enhanced (lymphoid tissue, pituitary gland, skin)

Subcell location

Nucleoplasm, Plasma membrane, Actin filaments, Focal adhesion sites

Predicted location

Membrane, Secreted - unknown location

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins

Chromosome

1 (6460786 - 6466175)

Ensembl ID

ENSG00000215788  (ver. 103.38)

Orthologs

Mouse Tnfrsf25: ENSMUSG00000024793

UniProt

Q93038

neXtProt

NX_Q93038

Human splice variants
Mouse splice variants

Protein structure