VSIG4

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Description

V-set and immunoglobulin domain containing 4

Tissue specificity

Tissue enhanced (lung)

Subcell location

Nucleoli, Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (66021738 - 66040125)

Ensembl ID

ENSG00000155659  (ver. 103.38)

Orthologs

Mouse Vsig4: ENSMUSG00000044206

UniProt

Q9Y279

neXtProt

NX_Q9Y279

Human splice variants
Mouse splice variants

Protein structure