Tissue expression
Cell line expression
Protein structure
PRKAG3
Protein kinase AMP-activated non-catalytic subunit gamma 3The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
LSBio | LS-C682447 | Monoclonal |
WB
EL
ICC
IHC |
||
antibodies-online | ABIN5682447 | Monoclonal |
WB
EL
ICC
IHC
FC
|
||
Invitrogen Antibodies | MA5-31868 | Monoclonal |
WB
EL
ICC
IHC |
||
Novus Biologicals | NBP2-61796 | Monoclonal |
WB
EL
ICC
IHC |
||
Abgent | AP7050c | 2 references | Polyclonal |
WB
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider