ACSS2

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Description

Acyl-CoA synthetase short chain family member 2

Tissue specificity

Tissue enhanced (skeletal muscle)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (34872146 - 34927962)

Ensembl ID

ENSG00000131069  (ver. 103.38)

Orthologs

Mouse Acss2: ENSMUSG00000027605

UniProt

Q9NR19

neXtProt

NX_Q9NR19

Human splice variants
Mouse splice variants

Protein structure