KCNK3

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Description

Potassium two pore domain channel subfamily K member 3

Tissue specificity

Tissue enriched (adrenal gland)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

2 (26692690 - 26733420)

Ensembl ID

ENSG00000171303  (ver. 103.38)

Orthologs

Mouse Kcnk3: ENSMUSG00000049265

UniProt

O14649

neXtProt

NX_O14649

Human splice variants
Mouse splice variants

Protein structure