Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 15212-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15212-1-AP, RRID:AB_2156759
- Product name
- OGDH antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OGDH antibody (Cat. #15212-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Citrate Synthase and OGDH as Potential Biomarkers of Atherosclerosis under Chronic Stress.
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection.
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
A glycolytic shift in Schwann cells supports injured axons.
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
α-Ketoglutarate links p53 to cell fate during tumour suppression.
Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells.
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation.
Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats.
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.
Energy Metabolism in the Bone is Associated with Histomorphometric Changes in Rats with Hyperthyroidism.
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Amplification of USP13 drives ovarian cancer metabolism.
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments.
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway.
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease.
Meng LB, Hu GF, Shan MJ, Zhang YM, Yu ZM, Liu YQ, Xu HX, Wang L, Gong T, Liu DP
Oxidative medicine and cellular longevity 2021;2021:9957908
Oxidative medicine and cellular longevity 2021;2021:9957908
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q
Cell research 2021 Sep;31(9):980-997
Cell research 2021 Sep;31(9):980-997
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
Trefely S, Huber K, Liu J, Noji M, Stransky S, Singh J, Doan MT, Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao S, Xu JP, Bedi KC Jr, Rame JE, Bogner-Strauss JG, Mesaros C, Sidoli S, Wellen KE, Snyder NW
Molecular cell 2021 Nov 22;
Molecular cell 2021 Nov 22;
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
Huang N, Li F, Zhang M, Zhou H, Chen Z, Ma X, Yang L, Wu X, Zhong J, Xiao F, Yang X, Zhao K, Li X, Xia X, Liu Z, Gao S, Zhang N
Cell metabolism 2021 Jan 5;33(1):128-144.e9
Cell metabolism 2021 Jan 5;33(1):128-144.e9
Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.
Watanabe K, Nagao M, Toh R, Irino Y, Shinohara M, Iino T, Yoshikawa S, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI
Biochemical and biophysical research communications 2021 Jan 1;534:687-693
Biochemical and biophysical research communications 2021 Jan 1;534:687-693
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection.
Li M, Yang J, Ye C, Bian P, Yang X, Zhang H, Luo C, Xue Z, Lei Y, Lian J
Virologica Sinica 2021 Dec;36(6):1554-1565
Virologica Sinica 2021 Dec;36(6):1554-1565
Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.
Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069
The EMBO journal 2021 Dec 15;40(24):e108069
A glycolytic shift in Schwann cells supports injured axons.
Babetto E, Wong KM, Beirowski B
Nature neuroscience 2020 Oct;23(10):1215-1228
Nature neuroscience 2020 Oct;23(10):1215-1228
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen X
Journal of hepatology 2020 May;72(5):909-923
Journal of hepatology 2020 May;72(5):909-923
Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation.
Dobolyi A, Bago A, Palkovits M, Nemeria NS, Jordan F, Doczi J, Ambrus A, Adam-Vizi V, Chinopoulos C
Brain structure & function 2020 Mar;225(2):639-667
Brain structure & function 2020 Mar;225(2):639-667
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E, Finley LWS
Nature cell biology 2020 Jul;22(7):779-790
Nature cell biology 2020 Jul;22(7):779-790
Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function.
Kľučková K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):303-315
Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model.
Wang T, Yao J, Chen S, Mao Z, Brinton RD
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):178-188
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):178-188
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
α-Ketoglutarate links p53 to cell fate during tumour suppression.
Morris JP 4th, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS, Lowe SW
Nature 2019 Sep;573(7775):595-599
Nature 2019 Sep;573(7775):595-599
Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells.
Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, Wei K, Li F, Lv J, Xie J, Liu Y, Huang B
Oncogene 2019 Oct;38(44):6970-6984
Oncogene 2019 Oct;38(44):6970-6984
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation.
Seim GL, Britt EC, John SV, Yeo FJ, Johnson AR, Eisenstein RS, Pagliarini DJ, Fan J
Nature metabolism 2019 Jul;1(7):731-742
Nature metabolism 2019 Jul;1(7):731-742
Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats.
Miura Y, Hayakawa A, Kikuchi S, Tsumoto H, Umezawa K, Chiba Y, Soejima Y, Sawabe M, Fukui K, Akimoto Y, Endo T
Archives of biochemistry and biophysics 2019 Dec 15;678:108167
Archives of biochemistry and biophysics 2019 Dec 15;678:108167
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.
Graham LC, Naldrett MJ, Kohama SG, Smith C, Lamont DJ, McColl BW, Gillingwater TH, Skehel P, Urbanski HF, Wishart TM
Cell reports 2019 Apr 23;27(4):1018-1026.e4
Cell reports 2019 Apr 23;27(4):1018-1026.e4
Energy Metabolism in the Bone is Associated with Histomorphometric Changes in Rats with Hyperthyroidism.
Hu Z, Du M, Lai W, Liang Y, Liu Q, Mo Y, Bei J, Li S, Yang Y, Xu J, Cui L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(4):1471-1482
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(4):1471-1482
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, Valsecchi F, Primiano G, Calder EL, Carelli V, Denton TT, Beal MF, Gross SS, Manfredi G, D'Aurelio M
Cell metabolism 2018 May 1;27(5):1007-1025.e5
Cell metabolism 2018 May 1;27(5):1007-1025.e5
Ifi27 is indispensable for mitochondrial function and browning in adipocytes.
Jin W, Jin W, Pan D
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
Biochemical and biophysical research communications 2018 Jun 18;501(1):273-279
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Wu L, Cao KX, Ni ZH, Li WD, Chen ZP, Cheng HB, Liu X
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.
Graham LC, Eaton SL, Brunton PJ, Atrih A, Smith C, Lamont DJ, Gillingwater TH, Pennetta G, Skehel P, Wishart TM
Molecular neurodegeneration 2017 Oct 27;12(1):77
Molecular neurodegeneration 2017 Oct 27;12(1):77
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology 2017 Mar 6;216(3):675-693
The Journal of cell biology 2017 Mar 6;216(3):675-693
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343
Oncotarget 2017 Dec 26;8(69):114328-114343
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH.
Allen EL, Ulanet DB, Pirman D, Mahoney CE, Coco J, Si Y, Chen Y, Huang L, Ren J, Choe S, Clasquin MF, Artin E, Fan ZP, Cianchetta G, Murtie J, Dorsch M, Jin S, Smolen GA
Cell reports 2016 Oct 11;17(3):876-890
Cell reports 2016 Oct 11;17(3):876-890
Amplification of USP13 drives ovarian cancer metabolism.
Han C, Yang L, Choi HH, Baddour J, Achreja A, Liu Y, Li Y, Li J, Wan G, Huang C, Ji G, Zhang X, Nagrath D, Lu X
Nature communications 2016 Nov 28;7:13525
Nature communications 2016 Nov 28;7:13525
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 8;111(27):9983-8
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 8;111(27):9983-8
Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments.
Yao J, Zhao L, Mao Z, Chen S, Wong KC, To J, Brinton RD
Brain research 2013 Jun 13;1514:128-41
Brain research 2013 Jun 13;1514:128-41
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway.
Jiang T, Yin F, Yao J, Brinton RD, Cadenas E
Aging cell 2013 Dec;12(6):1021-31
Aging cell 2013 Dec;12(6):1021-31
2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease.
Yao J, Chen S, Mao Z, Cadenas E, Brinton RD
PloS one 2011;6(7):e21788
PloS one 2011;6(7):e21788
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 15212-1-AP( OGDH Antibody) at dilution of 1:3000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using OGDH antibody 15212-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line