BS8180

antibody from Bioworld Technology, Inc

Targeting: OGDH E1k, KGD1, OGDC-E1, OGDH2

Immunohistochemistry

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Validation data

Product number: BS8180 - Provider product page
Provider: Bioworld Technology, Inc
Product name: OGDH polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human OGDH.
Description: The Ï«-ketoglutarate dehydrogenase (Ï«-KGD) complex is a multienzyme complex which localizes to the mitochondrial matrix and consists of three protein subunits: Ï«-ketoglutarate dehydrogenase, also designated Ï«-KGD, E1k or oxoglutarate dehydrogenase (OGDH); dihydrolipoyl succinyltransferase (E2k or DLST); and dihydrolipoyl dehydrogenase (E3). The Ï«-KGD subunit of the Ï«-KGD complex catalyzes the conversion of Ï«-ketoglutarate to succinyl-CoA and CO2, an essential reaction of the tricarboxylic acid cycle. A definciency in Ï«-KGD results in hypotonia, metabolic acidosis, hyperlactatemia immediately after birth, and neurologic deterioration resulting in death at about 30 months of age. Low molar ratios of ketone bodies in plasma of neonates with congenital lactic acidosis are proposed indicators of tricarboxylic acid cycle dysfunction.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

OGDH protein structure - BS8180 shown in red.