UTS2

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Urotensin 2

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

1 (7843083 - 7853512)

Ensembl ID

ENSG00000049247  (ver. 103.38)

Orthologs

Mouse Uts2: ENSMUSG00000028963

UniProt

O95399

neXtProt

NX_O95399

Human splice variants
Mouse splice variants

Protein structure