DDX27

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

Description

DEAD-box helicase 27

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli

Predicted location

Intracellular

Protein family

Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

20 (49219347 - 49244077)

Ensembl ID

ENSG00000124228  (ver. 103.38)

Orthologs

Mouse Ddx27: ENSMUSG00000017999

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure