BS7953

antibody from Bioworld Technology, Inc
Targeting: HSD17B4 DBP, MFE-2, SDR8C1
Provider product page for BS7953
Western blot
Immunohistochemistry

Antibody data

Product number
BS7953 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HSD17B4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HSD17B4.
Description
17ÉÇ-HSD4 (17ÉÇ-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-ÉÇ Estradiol dehydrogenase type IV. It belongs to the 17ÉÇ-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17ÉÇ-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol ?-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17ÉÇ-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17ÉÇ-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HSD17B4 protein structure - BS7953 shown in red.