ADGRE2

This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Description

Adhesion G protein-coupled receptor E2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Vesicles, Cytosol

Predicted location

Membrane

Protein family

CD markers
Disease related genes
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

19 (14732392 - 14778560)

Ensembl ID

ENSG00000127507  (ver. 103.38)

Orthologs

-

UniProt

Q9UHX3

neXtProt

NX_Q9UHX3

Human splice variants

Protein structure