GNAT1

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Description

G protein subunit alpha transducin 1

Tissue specificity

Tissue enriched (retina)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (50191610 - 50197696)

Ensembl ID

ENSG00000114349  (ver. 103.38)

Orthologs

Mouse Gnat1: ENSMUSG00000034837

UniProt

P11488

neXtProt

NX_P11488

Human splice variants
Mouse splice variants

Protein structure