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UBE2D1
Ubiquitin conjugating enzyme E2 D1E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Top validated antibodies |
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| NSJ Bioreagents |  RQ6217 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| antibodies-online | ABIN393588 |
5 references | Monoclonal |
WB
EL
IHC
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| Boster Biological Technology | A04728-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
|
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| Novus Biologicals | H00007321-M01 |
1 references | Monoclonal |
WB
EL
IHC
|
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| Abnova Corporation | H00007321-M01 |
1 references | Monoclonal |
WB
EL
IHC
|
|
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