HOXA1

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]

Description

Homeobox A1

Tissue specificity

Tissue enhanced (urinary bladder)

Predicted location

Intracellular

Protein family

Human disease related genes
Predicted intracellular proteins

Chromosome

7 (27092993 - 27096000)

Ensembl ID

ENSG00000105991  (ver. 103.38)

Orthologs

Mouse Hoxa1: ENSMUSG00000029844

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure