Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
MCM3
Minichromosome maintenance complex component 3The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
Top validated antibodies |
|||||
| GeneTex |  GTX110241 |
2 references | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
|
| antibodies-online | ABIN393375 |
5 references | Monoclonal |
WB
EL
ICC
IHC
|
|
| Invitrogen Antibodies | PA5-29106 |
Polyclonal |
WB
ICC
IHC
ChIP
OA
|
||
| Proteintech Group | 15597-1-AP |
8 references | Polyclonal |
WB
EL
IP
IHC
|
|
| Novus Biologicals | NB100-289 |
3 references | Polyclonal |
WB
IP
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider