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LearnABIN152902
antibody from antibodies-online
Targeting: MLXIPL
bHLHd14, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH
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- Antigen structure
- References [89]
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- Western blot [2]
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- Product number
- ABIN152902 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-MLX Interacting Protein-Like (MLXIPL) (AA 800-852), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- AA 800-852, C-Term
- Vial size
- 0.1 mL
- Storage
- Store at 4°C. Do not freeze.
- Handling
- Do not freeze.
Submitted references Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.
Aralia elata (Miq) Seem Extract Decreases O-GlcNAc Transferase Expression and Retinal Cell Death in Diabetic Mice.
Metformin protects against retinal cell death in diabetic mice.
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.
The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor.
LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice.
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.
Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism.
ChREBP regulates fructose-induced glucose production independently of insulin signaling.
High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.
Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.
FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance.
The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARγ Activity and Adipocyte Differentiation.
Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin.
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.
New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells.
Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.
High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia.
Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver.
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction.
Hepatic fatty acid and cholesterol metabolism in nephrotic syndrome.
Oleanolic Acid diminishes liquid fructose-induced Fatty liver in rats: role of modulation of hepatic sterol regulatory element-binding protein-1c-mediated expression of genes responsible for de novo Fatty Acid synthesis.
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.
Flightless I homolog negatively regulates ChREBP activity in cancer cells.
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.
Dysregulation of hepatic fatty acid metabolism in chronic kidney disease.
Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.
Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats.
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation.
Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis.
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.
Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver.
Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein.
Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.
Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.
LRH-1-dependent glucose sensing determines intermediary metabolism in liver.
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
Age-related differences in naturally acquired T cell memory to Plasmodium falciparum merozoite surface protein 1.
Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.
Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.
Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes.
Reduced impact logging minimally alters tropical rainforest carbon and energy exchange.
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.
Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.
Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.
c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.
Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.
Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter.
Crystal structure of a virus-encoded putative glycosyltransferase.
Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate.
Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains.
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter.
Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.
Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation.
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma.
Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition.
Detailed molecular analysis of the induction of the L-PK gene by glucose.
The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase.
Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat.
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.
Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA
Cell metabolism 2018 Jan 9;27(1):195-209.e6
Cell metabolism 2018 Jan 9;27(1):195-209.e6
Aralia elata (Miq) Seem Extract Decreases O-GlcNAc Transferase Expression and Retinal Cell Death in Diabetic Mice.
Kim YS, Kim M, Choi MY, Lee DH, Roh GS, Kim HJ, Kang SS, Cho GJ, Park KH, Kim SJ, Yoo JM, Choi WS
Journal of medicinal food 2017 Oct;20(10):989-1001
Journal of medicinal food 2017 Oct;20(10):989-1001
Metformin protects against retinal cell death in diabetic mice.
Kim YS, Kim M, Choi MY, Lee DH, Roh GS, Kim HJ, Kang SS, Cho GJ, Kim SJ, Yoo JM, Choi WS
Biochemical and biophysical research communications 2017 Oct 21;492(3):397-403
Biochemical and biophysical research communications 2017 Oct 21;492(3):397-403
A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.
Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C
Cell reports 2017 Oct 10;21(2):403-416
Cell reports 2017 Oct 10;21(2):403-416
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR
The Journal of clinical investigation 2017 Nov 1;127(11):4059-4074
The Journal of clinical investigation 2017 Nov 1;127(11):4059-4074
Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia.
Cho JH, Kim GY, Pan CJ, Anduaga J, Choi EJ, Mansfield BC, Chou JY
PLoS genetics 2017 May;13(5):e1006819
PLoS genetics 2017 May;13(5):e1006819
An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.
Janssens S, Ciapaite J, Wolters JC, van Riel NA, Nicolay K, Prompers JJ
Nutrients 2017 May 10;9(5)
Nutrients 2017 May 10;9(5)
The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor.
Na TY, Kim GH, Oh HJ, Lee MH, Han YH, Kim KT, Kim JS, Kim DD, Lee MO
Scientific reports 2017 Mar 7;7:43823
Scientific reports 2017 Mar 7;7:43823
LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice.
Fan Q, Nørgaard RC, Bindesbøll C, Lucas C, Dalen KT, Babaie E, Itkonen HM, Matthews J, Nebb HI, Grønning-Wang LM
Nutrients 2017 Jun 29;9(7)
Nutrients 2017 Jun 29;9(7)
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Cao W, Chang T, Li XQ, Wang R, Wu L
Clinical science (London, England : 1979) 2017 Feb 1;131(4):309-325
Clinical science (London, England : 1979) 2017 Feb 1;131(4):309-325
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
Kim M, Astapova II, Flier SN, Hannou SA, Doridot L, Sargsyan A, Kou HH, Fowler AJ, Liang G, Herman MA
JCI insight 2017 Dec 21;2(24)
JCI insight 2017 Dec 21;2(24)
Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.
Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L
Diabetes, obesity & metabolism 2017 Aug;19(8):1078-1087
Diabetes, obesity & metabolism 2017 Aug;19(8):1078-1087
Retinol saturase coordinates liver metabolism by regulating ChREBP activity.
Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Döcke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M
Nature communications 2017 Aug 30;8(1):384
Nature communications 2017 Aug 30;8(1):384
The effects of prenatal metformin on obesogenic diet-induced alterations in maternal and fetal fatty acid metabolism.
Harris K, Desai N, Gupta M, Xue X, Chatterjee PK, Rochelson B, Metz CN
Nutrition & metabolism 2016;13(1):55
Nutrition & metabolism 2016;13(1):55
ChREBP regulates fructose-induced glucose production independently of insulin signaling.
Kim MS, Krawczyk SA, Doridot L, Fowler AJ, Wang JX, Trauger SA, Noh HL, Kang HJ, Meissen JK, Blatnik M, Kim JK, Lai M, Herman MA
The Journal of clinical investigation 2016 Nov 1;126(11):4372-4386
The Journal of clinical investigation 2016 Nov 1;126(11):4372-4386
High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M
Physiological reports 2016 Mar;4(6)
Physiological reports 2016 Mar;4(6)
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L
Toxicology and applied pharmacology 2016 Jul 15;303:90-100
Toxicology and applied pharmacology 2016 Jul 15;303:90-100
Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.
Zhang Z, Li B, Meng X, Yao S, Jin L, Yang J, Wang J, Zhang H, Zhang Z, Cai D, Zhang Y, Ning G
Scientific reports 2016 Feb 9;6:20848
Scientific reports 2016 Feb 9;6:20848
Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.
Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S
Cell reports 2016 Aug 30;16(9):2359-72
Cell reports 2016 Aug 30;16(9):2359-72
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA
Nature communications 2016 Apr 21;7:11365
Nature communications 2016 Apr 21;7:11365
Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.
Marmier S, Dentin R, Daujat-Chavanieu M, Guillou H, Bertrand-Michel J, Gerbal-Chaloin S, Girard J, Lotersztajn S, Postic C
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1086-100
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1086-100
FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance.
Nuotio-Antar AM, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, Zou F, Chan L
Endocrinology 2015 Nov;156(11):4020-32
Endocrinology 2015 Nov;156(11):4020-32
The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARγ Activity and Adipocyte Differentiation.
Witte N, Muenzner M, Rietscher J, Knauer M, Heidenreich S, Nuotio-Antar AM, Graef FA, Fedders R, Tolkachov A, Goehring I, Schupp M
Endocrinology 2015 Nov;156(11):4008-19
Endocrinology 2015 Nov;156(11):4008-19
Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin.
Poungvarin N, Chang B, Imamura M, Chen J, Moolsuwan K, Sae-Lee C, Li W, Chan L
Endocrinology 2015 Jun;156(6):1982-94
Endocrinology 2015 Jun;156(6):1982-94
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, Spinelli V, Hennuyer N, Caron S, Bantubungi K, Caiazzo R, Reimann F, Marchetti P, Lefebvre P, Bäckhed F, Gribble FM, Schoonjans K, Pattou F, Tailleux A, Staels B, Lestavel S
Nature communications 2015 Jul 2;6:7629
Nature communications 2015 Jul 2;6:7629
MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.
Kaadige MR, Yang J, Wilde BR, Ayer DE
Molecular and cellular biology 2015 Jan;35(1):101-10
Molecular and cellular biology 2015 Jan;35(1):101-10
New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells.
Li X, Kover KL, Heruth DP, Watkins DJ, Moore WV, Jackson K, Zang M, Clements MA, Yan Y
Molecular endocrinology (Baltimore, Md.) 2015 Aug;29(8):1184-94
Molecular endocrinology (Baltimore, Md.) 2015 Aug;29(8):1184-94
Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity.
Bindesbøll C, Fan Q, Nørgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TÅ, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Grønning-Wang LM
Journal of lipid research 2015 Apr;56(4):771-85
Journal of lipid research 2015 Apr;56(4):771-85
High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia.
Chang ML, Chiu CJ, Shang F, Taylor A
Advances in experimental medicine and biology 2014;801:609-21
Advances in experimental medicine and biology 2014;801:609-21
Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver.
Xing X, Li D, Chen D, Zhou L, Chonan R, Yamahara J, Wang J, Li Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):207-15
Toxicology and applied pharmacology 2014 Oct 15;280(2):207-15
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Cortés VA, Cautivo KM, Rong S, Garg A, Horton JD, Agarwal AK
Journal of lipid research 2014 Feb;55(2):276-88
Journal of lipid research 2014 Feb;55(2):276-88
Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction.
Gupta M, Solanki MH, Chatterjee PK, Xue X, Roman A, Desai N, Rochelson B, Metz CN
Molecular medicine (Cambridge, Mass.) 2014 Aug 14;20:332-40
Molecular medicine (Cambridge, Mass.) 2014 Aug 14;20:332-40
Hepatic fatty acid and cholesterol metabolism in nephrotic syndrome.
Han S, Vaziri ND, Gollapudi P, Kwok V, Moradi H
American journal of translational research 2013;5(2):246-53
American journal of translational research 2013;5(2):246-53
Oleanolic Acid diminishes liquid fructose-induced Fatty liver in rats: role of modulation of hepatic sterol regulatory element-binding protein-1c-mediated expression of genes responsible for de novo Fatty Acid synthesis.
Liu C, Li Y, Zuo G, Xu W, Gao H, Yang Y, Yamahara J, Wang J, Li Y
Evidence-based complementary and alternative medicine : eCAM 2013;2013:534084
Evidence-based complementary and alternative medicine : eCAM 2013;2013:534084
PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.
Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN
Molecular metabolism 2013;2(3):194-204
Molecular metabolism 2013;2(3):194-204
Flightless I homolog negatively regulates ChREBP activity in cancer cells.
Wu L, Chen H, Zhu Y, Meng J, Li Y, Li M, Yang D, Zhang P, Feng M, Tong X
The international journal of biochemistry & cell biology 2013 Nov;45(11):2688-97
The international journal of biochemistry & cell biology 2013 Nov;45(11):2688-97
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.
Caron S, Huaman Samanez C, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B
Molecular and cellular biology 2013 Jun;33(11):2202-11
Molecular and cellular biology 2013 Jun;33(11):2202-11
Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.
Petrie JL, Al-Oanzi ZH, Arden C, Tudhope SJ, Mann J, Kieswich J, Yaqoob MM, Towle HC, Agius L
Molecular and cellular biology 2013 Feb;33(4):725-38
Molecular and cellular biology 2013 Feb;33(4):725-38
Dysregulation of hepatic fatty acid metabolism in chronic kidney disease.
Jin K, Norris K, Vaziri ND
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013 Feb;28(2):313-20
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013 Feb;28(2):313-20
Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice.
Jo SH, Kim MY, Park JM, Kim TH, Ahn YH
Diabetologia 2013 Dec;56(12):2723-32
Diabetologia 2013 Dec;56(12):2723-32
Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats.
Liu L, Yang M, Lin X, Li Y, Liu C, Yang Y, Yamahara J, Wang J, Li Y
Journal of ethnopharmacology 2013 Dec 12;150(3):1045-52
Journal of ethnopharmacology 2013 Dec 12;150(3):1045-52
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J
Journal of the American Heart Association 2013 Apr 5;2(2):e000093
Journal of the American Heart Association 2013 Apr 5;2(2):e000093
Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation.
Ido-Kitamura Y, Sasaki T, Kobayashi M, Kim HJ, Lee YS, Kikuchi O, Yokota-Hashimoto H, Iizuka K, Accili D, Kitamura T
PloS one 2012;7(10):e47231
PloS one 2012;7(10):e47231
Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.
Shao W, Yu Z, Chiang Y, Yang Y, Chai T, Foltz W, Lu H, Fantus IG, Jin T
PloS one 2012;7(1):e28784
PloS one 2012;7(1):e28784
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.
Zhang YK, Wu KC, Liu J, Klaassen CD
Toxicology and applied pharmacology 2012 Nov 1;264(3):305-14
Toxicology and applied pharmacology 2012 Nov 1;264(3):305-14
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Rüegg MA, Hall MN
Cell metabolism 2012 May 2;15(5):725-38
Cell metabolism 2012 May 2;15(5):725-38
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis.
Perttilä J, Huaman-Samanez C, Caron S, Tanhuanpää K, Staels B, Yki-Järvinen H, Olkkonen VM
American journal of physiology. Endocrinology and metabolism 2012 May 15;302(9):E1063-9
American journal of physiology. Endocrinology and metabolism 2012 May 15;302(9):E1063-9
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans.
Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset C, Capeau J, Girard J, Guillou H, Postic C
The Journal of clinical investigation 2012 Jun;122(6):2176-94
The Journal of clinical investigation 2012 Jun;122(6):2176-94
Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver.
Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferré P
Journal of hepatology 2012 Jan;56(1):199-209
Journal of hepatology 2012 Jan;56(1):199-209
Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein.
Iizuka K, Tomita R, Takeda J, Horikawa Y
Biochemical and biophysical research communications 2012 Jan 27;417(4):1107-12
Biochemical and biophysical research communications 2012 Jan 27;417(4):1107-12
Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.
Marmugi A, Ducheix S, Lasserre F, Polizzi A, Paris A, Priymenko N, Bertrand-Michel J, Pineau T, Guillou H, Martin PG, Mselli-Lakhal L
Hepatology (Baltimore, Md.) 2012 Feb;55(2):395-407
Hepatology (Baltimore, Md.) 2012 Feb;55(2):395-407
Peroxisome proliferator-activated receptor-α agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis.
Larter CZ, Yeh MM, Van Rooyen DM, Brooling J, Ghatora K, Farrell GC
Journal of gastroenterology and hepatology 2012 Feb;27(2):341-50
Journal of gastroenterology and hepatology 2012 Feb;27(2):341-50
LRH-1-dependent glucose sensing determines intermediary metabolism in liver.
Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K
The Journal of clinical investigation 2012 Aug;122(8):2817-26
The Journal of clinical investigation 2012 Aug;122(8):2817-26
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.
Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L
The Biochemical journal 2012 Apr 1;443(1):111-23
The Biochemical journal 2012 Apr 1;443(1):111-23
Age-related differences in naturally acquired T cell memory to Plasmodium falciparum merozoite surface protein 1.
Chelimo K, Embury PB, Sumba PO, Vulule J, Ofulla AV, Long C, Kazura JW, Moormann AM
PloS one 2011;6(9):e24852
PloS one 2011;6(9):e24852
Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
PloS one 2011;6(8):e22976
PloS one 2011;6(8):e22976
Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.
Jeong YS, Kim D, Lee YS, Kim HJ, Han JY, Im SS, Chong HK, Kwon JK, Cho YH, Kim WK, Osborne TF, Horton JD, Jun HS, Ahn YH, Ahn SM, Cha JY
PloS one 2011;6(7):e22544
PloS one 2011;6(7):e22544
Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase.
Vidal-Alabró A, Gómez-Valadés AG, Méndez-Lucas A, Llorens J, Bartrons R, Bermúdez J, Perales JC
International journal of endocrinology 2011;2011:707928
International journal of endocrinology 2011;2011:707928
Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes.
Iizuka K, Takeda J, Horikawa Y
Biochemical and biophysical research communications 2011 Sep 9;412(4):638-43
Biochemical and biophysical research communications 2011 Sep 9;412(4):638-43
Reduced impact logging minimally alters tropical rainforest carbon and energy exchange.
Miller SD, Goulden ML, Hutyra LR, Keller M, Saleska SR, Wofsy SC, Figueira AM, da Rocha HR, de Camargo PB
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 29;108(48):19431-5
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 29;108(48):19431-5
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.
Guinez C, Filhoulaud G, Rayah-Benhamed F, Marmier S, Dubuquoy C, Dentin R, Moldes M, Burnol AF, Yang X, Lefebvre T, Girard J, Postic C
Diabetes 2011 May;60(5):1399-413
Diabetes 2011 May;60(5):1399-413
Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Inoue J, Yamasaki K, Ikeuchi E, Satoh S, Fujiwara Y, Nishimaki-Mogami T, Shimizu M, Sato R
Molecular endocrinology (Baltimore, Md.) 2011 Jun;25(6):995-1005
Molecular endocrinology (Baltimore, Md.) 2011 Jun;25(6):995-1005
Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.
Arden C, Petrie JL, Tudhope SJ, Al-Oanzi Z, Claydon AJ, Beynon RJ, Towle HC, Agius L
Diabetes 2011 Dec;60(12):3110-20
Diabetes 2011 Dec;60(12):3110-20
Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
Feingold KR, Shigenaga JK, Patzek SM, Chui LG, Moser A, Grunfeld C
Innate immunity 2011 Apr;17(2):174-82
Innate immunity 2011 Apr;17(2):174-82
ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.
Boergesen M, Poulsen Ll, Schmidt SF, Frigerio F, Maechler P, Mandrup S
The Journal of biological chemistry 2011 Apr 15;286(15):13214-25
The Journal of biological chemistry 2011 Apr 15;286(15):13214-25
c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes.
Zhang P, Metukuri MR, Bindom SM, Prochownik EV, O'Doherty RM, Scott DK
Molecular endocrinology (Baltimore, Md.) 2010 Jun;24(6):1274-86
Molecular endocrinology (Baltimore, Md.) 2010 Jun;24(6):1274-86
Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: discovery of a new leucine-rich nuclear export signal site.
Fukasawa M, Ge Q, Wynn RM, Ishii S, Uyeda K
Biochemical and biophysical research communications 2010 Jan 8;391(2):1166-9
Biochemical and biophysical research communications 2010 Jan 8;391(2):1166-9
Glucose induces expression of rat pyruvate carboxylase through a carbohydrate response element in the distal gene promoter.
Pedersen KB, Buckley RS, Scioneaux R
The Biochemical journal 2010 Feb 9;426(2):159-70
The Biochemical journal 2010 Feb 9;426(2):159-70
Crystal structure of a virus-encoded putative glycosyltransferase.
Xiang Y, Baxa U, Zhang Y, Steven AC, Lewis GL, Van Etten JL, Rossmann MG
Journal of virology 2010 Dec;84(23):12265-73
Journal of virology 2010 Dec;84(23):12265-73
Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate.
Yu FX, Chai TF, He H, Hagen T, Luo Y
The Journal of biological chemistry 2010 Aug 13;285(33):25822-30
The Journal of biological chemistry 2010 Aug 13;285(33):25822-30
Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains.
Ferreira DM, Moreno AT, Cianciarullo AM, Ho PL, Oliveira ML, Miyaji EN
Microbial pathogenesis 2009 Sep;47(3):157-63
Microbial pathogenesis 2009 Sep;47(3):157-63
cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.
Burke SJ, Collier JJ, Scott DK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2855-65
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2855-65
cAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter.
Burke SJ, Collier JJ, Scott DK
Journal of molecular biology 2009 Sep 25;392(3):578-88
Journal of molecular biology 2009 Sep 25;392(3):578-88
Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.
Bu SY, Mashek MT, Mashek DG
The Journal of biological chemistry 2009 Oct 30;284(44):30474-83
The Journal of biological chemistry 2009 Oct 30;284(44):30474-83
Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.
Moon YA, Hammer RE, Horton JD
Journal of lipid research 2009 Mar;50(3):412-23
Journal of lipid research 2009 Mar;50(3):412-23
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Kim HJ, Moradi H, Yuan J, Norris K, Vaziri ND
American journal of physiology. Renal physiology 2009 Jun;296(6):F1297-306
American journal of physiology. Renal physiology 2009 Jun;296(6):F1297-306
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.
Butcher AJ, Torrecilla I, Young KW, Kong KC, Mistry SC, Bottrill AR, Tobin AB
The Journal of biological chemistry 2009 Jun 19;284(25):17147-56
The Journal of biological chemistry 2009 Jun 19;284(25):17147-56
Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.
Cha-Molstad H, Saxena G, Chen J, Shalev A
The Journal of biological chemistry 2009 Jun 19;284(25):16898-905
The Journal of biological chemistry 2009 Jun 19;284(25):16898-905
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation.
Tong X, Zhao F, Mancuso A, Gruber JJ, Thompson CB
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 22;106(51):21660-5
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 22;106(51):21660-5
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Sirek AS, Liu L, Naples M, Adeli K, Ng DS, Jin T
Endocrinology 2009 Aug;150(8):3483-92
Endocrinology 2009 Aug;150(8):3483-92
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma.
Krishnamoorthy N, Oriss TB, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, Ray A, Ray P
Nature medicine 2008 May;14(5):565-73
Nature medicine 2008 May;14(5):565-73
Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition.
Wang Y, Torres-Gonzalez M, Tripathy S, Botolin D, Christian B, Jump DB
Journal of lipid research 2008 Jul;49(7):1538-52
Journal of lipid research 2008 Jul;49(7):1538-52
Detailed molecular analysis of the induction of the L-PK gene by glucose.
Eckert DT, Zhang P, Collier JJ, O'Doherty RM, Scott DK
Biochemical and biophysical research communications 2008 Jul 18;372(1):131-6
Biochemical and biophysical research communications 2008 Jul 18;372(1):131-6
The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase.
Aneja KK, Guha P, Shilpi RY, Chakraborty S, Schramm LM, Haldar D
Archives of biochemistry and biophysics 2008 Feb 1;470(1):35-43
Archives of biochemistry and biophysics 2008 Feb 1;470(1):35-43
Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat.
Erhuma A, Salter AM, Sculley DV, Langley-Evans SC, Bennett AJ
American journal of physiology. Endocrinology and metabolism 2007 Jun;292(6):E1702-14
American journal of physiology. Endocrinology and metabolism 2007 Jun;292(6):E1702-14
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair MG, Peters JM, Busik JV, Olson LK, Jump DB
Journal of lipid research 2006 Sep;47(9):2028-41
Journal of lipid research 2006 Sep;47(9):2028-41
Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase.
Adamson AW, Suchankova G, Rufo C, Nakamura MT, Teran-Garcia M, Clarke SD, Gettys TW
The Biochemical journal 2006 Oct 15;399(2):285-95
The Biochemical journal 2006 Oct 15;399(2):285-95
Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
Xu J, Christian B, Jump DB
The Journal of biological chemistry 2006 Jul 7;281(27):18351-62
The Journal of biological chemistry 2006 Jul 7;281(27):18351-62
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.
Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C
Diabetes 2006 Aug;55(8):2159-70
Diabetes 2006 Aug;55(8):2159-70
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Supportive validation
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Supportive validation
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- Submitted by
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