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LearnTissue expression
Cell line expression
Protein structure
CSF2
Colony stimulating factor 2GM-CSF, GMCSF
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Abgent |  AH10097 |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
BN
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| Novus Biologicals | NBP2-34570-0.1 mg |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
BN
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| R&D Systems | MAB5181 |
2 references | Monoclonal |
WB
ICC
FC
BN
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| antibodies-online | ABIN704156 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| OriGene | AM33269PU-S |
Monoclonal |
WB
ICC
IP
IHC
FC
BN
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