FBXO42

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Dec 2010]

Description

F-box protein 42

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (16246840 - 16352480)

Ensembl ID

ENSG00000037637  (ver. 103.38)

Orthologs

Mouse Fbxo42: ENSMUSG00000028920

UniProt

Q6P3S6

neXtProt

NX_Q6P3S6

Human splice variants
Mouse splice variants

Protein structure