IL24

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

Interleukin 24

Tissue specificity

Group enriched (intestine, lymphoid tissue, urinary bladder)

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins

Chromosome

1 (206897443 - 206904139)

Ensembl ID

ENSG00000162892  (ver. 103.38)

Orthologs

Mouse Il24: ENSMUSG00000026420

UniProt

Q13007

neXtProt

NX_Q13007

Human splice variants
Mouse splice variants

Protein structure