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Protein structure
SNCA
Synuclein alphaNACP, PARK1, PARK4, PD1
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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| Invitrogen Antibodies |  AHB0261 |
22 references | Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| Proteintech Group | 10842-1-AP |
34 references | Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP1-05194 |
1 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| antibodies-online | ABIN439712 |
2 references | Monoclonal |
WB
ICC
IHC
FC
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| R&D Systems | AF1338 |
2 references | Polyclonal |
WB
EL
IHC
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