Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10842-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10842-1-AP, RRID:AB_2192672
- Product name
- Alpha Synuclein antibody
- Antibody type
- Polyclonal
- Description
- Alpha Synuclein antibody (Cat. #10842-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Myocardial cathepsin D is downregulated in sudden cardiac death.
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.
Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation.
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease.
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells.
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.
α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis.
Chang KH, Huang CY, Ou-Yang CH, Ho CH, Lin HY, Hsu CL, Chen YT, Chou YC, Chen YJ, Chen Y, Lin JL, Wang JK, Lin PW, Lin YR, Lin MH, Tseng CK, Lin CH
Stem cell research & therapy 2021 Sep 22;12(1):508
Stem cell research & therapy 2021 Sep 22;12(1):508
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Gao H, Wang D, Jiang S, Mao J, Yang X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.
Dong WL, Zhong JH, Chen YQ, Xie JF, Qin YY, Xu JP, Cai NB, Li MF, Liu L, Wang HT
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003
CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.
Liu B, Li H, Liu X, Li F, Chen W, Kuang Y, Zhao X, Li L, Yu B, Jin X, Li Q
Cellular signalling 2021 Aug;84:110012
Cellular signalling 2021 Aug;84:110012
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, Sun Z, Han Q, Zhao RC
Aging and disease 2021 Aug;12(5):1211-1222
Aging and disease 2021 Aug;12(5):1211-1222
Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.
Gao H, Wang D, Wang YL, Mao JP, Jiang S, Yang XL
Molecular biology reports 2021 Apr;48(4):3079-3087
Molecular biology reports 2021 Apr;48(4):3079-3087
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64
Acta neuropathologica communications 2021 Apr 8;9(1):64
Myocardial cathepsin D is downregulated in sudden cardiac death.
Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M
PloS one 2020;15(3):e0230375
PloS one 2020;15(3):e0230375
The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.
Akintade DD, Chaudhuri B
Bioscience reports 2020 Sep 30;40(9)
Bioscience reports 2020 Sep 30;40(9)
Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.
Akintade DD, Chaudhuri B
Cells 2020 Sep 29;9(10)
Cells 2020 Sep 29;9(10)
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Chiu CC, Weng YH, Huang YZ, Chen RS, Liu YC, Yeh TH, Lu CS, Lin YW, Chen YJ, Hsu CC, Chiu CH, Wang YT, Chen WS, Liu SY, Wang HL
Cell death & disease 2020 Nov 30;11(11):1018
Cell death & disease 2020 Nov 30;11(11):1018
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Akintade DD, Chaudhuri B
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q
PloS one 2019;14(11):e0225145
PloS one 2019;14(11):e0225145
Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.
Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL
Frontiers in cellular neuroscience 2019;13:399
Frontiers in cellular neuroscience 2019;13:399
Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.
Lin CJ, Lin CY, Lin YT, Huang CY, Wei KC, Chen JC, Lee-Chen GJ, Liu HL
Biochemical and biophysical research communications 2019 Sep 10;517(1):77-83
Biochemical and biophysical research communications 2019 Sep 10;517(1):77-83
Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation.
Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A
Molecular neurobiology 2019 Mar;56(3):1539-1557
Molecular neurobiology 2019 Mar;56(3):1539-1557
Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.
So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112
Behavioural brain research 2019 Mar 15;360:103-112
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.
Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL
Molecular neurobiology 2019 Jun;56(6):3835-3853
Molecular neurobiology 2019 Jun;56(6):3835-3853
Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.
Zhou P, Homberg JR, Fang Q, Wang J, Li W, Meng X, Shen J, Luan Y, Liao P, Swaab DF, Shan L, Liu C
Brain, behavior, and immunity 2019 Feb;76:61-73
Brain, behavior, and immunity 2019 Feb;76:61-73
RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease.
Su J, Wang H, Yang Y, Wang J, Li H, Huang D, Huang L, Bai X, Yu M, Fei J, Huang F
Neurochemistry international 2018 Sep;118:195-204
Neurochemistry international 2018 Sep;118:195-204
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F
Cell death & disease 2018 Jun 13;9(6):700
Cell death & disease 2018 Jun 13;9(6):700
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118
Neural regeneration research 2018 Jan;13(1):112-118
TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.
Koga S, Lin WL, Walton RL, Ross OA, Dickson DW
Neuropathology and applied neurobiology 2018 Dec;44(7):707-721
Neuropathology and applied neurobiology 2018 Dec;44(7):707-721
Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.
Huang C, Zhu L, Li H, Shi FG, Wang GQ, Wei YZ, Liu J, Zhang F
Frontiers in molecular neuroscience 2017;10:131
Frontiers in molecular neuroscience 2017;10:131
α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells.
Duan J, Ying Z, Su Y, Lin F, Deng Y
Neuroscience letters 2017 Mar 6;642:148-152
Neuroscience letters 2017 Mar 6;642:148-152
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
Tayebi N, Parisiadou L, Berhe B, Gonzalez AN, Serra-Vinardell J, Tamargo RJ, Maniwang E, Sorrentino Z, Fujiwara H, Grey RJ, Hassan S, Blech-Hermoni YN, Chen C, McGlinchey R, Makariou-Pikis C, Brooks M, Ginns EI, Ory DS, Giasson BI, Sidransky E
Molecular genetics and metabolism 2017 Dec;122(4):198-208
Molecular genetics and metabolism 2017 Dec;122(4):198-208
Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.
Marques F, Tenney J, Duran I, Martin J, Nevarez L, Pogue R, Krakow D, Cohn DH, Li B
PLoS genetics 2016 Sep;12(9):e1006307
PLoS genetics 2016 Sep;12(9):e1006307
Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.
Rodríguez-Nogales C, Garbayo E, Martínez-Valbuena I, Sebastián V, Luquin MR, Blanco-Prieto MJ
International journal of pharmaceutics 2016 Nov 30;514(1):142-149
International journal of pharmaceutics 2016 Nov 30;514(1):142-149
Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.
Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, Zhang G, Yang J, Zhang Z, Zhang Z, Lin Z, Xiong N, Wang T
Molecular neurobiology 2016 Mar;53(2):995-1008
Molecular neurobiology 2016 Mar;53(2):995-1008
Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 27;35(21):8345-58
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 27;35(21):8345-58
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J
Molecular neurodegeneration 2015 Mar 11;10:8
Molecular neurodegeneration 2015 Mar 11;10:8
Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.
Zhang Y, Ma H, Xie B, Han C, Wang C, Qing H, Deng Y
Neuroscience letters 2013 Jun 28;547:65-9
Neuroscience letters 2013 Jun 28;547:65-9
α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis.
Ying Z, Lin F, Gu W, Su Y, Arshad A, Qing H, Deng Y
Journal of neural transmission (Vienna, Austria : 1996) 2011 Aug;118(8):1165-72
Journal of neural transmission (Vienna, Austria : 1996) 2011 Aug;118(8):1165-72
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10842-1-AP(SNCA antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 10842-1-AP(SNCA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The alpha-synuclein antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human alpha-synuclein. This antibody recognizes human,mouse,rat antigen. The alpha-synuclein antibody has been validated for the following applications: ELISA, WB, IHC analysis.