ALX-804-258-L001

antibody from Enzo Life Sciences

Targeting: SNCA NACP, PARK1, PARK4, PD1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ALX-804-258-L001

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ALX-804-258-L001, RRID:AB_2050691

Product name

_-Synuclein (human) monoclonal antibody (15G7)

Antibody type

Monoclonal

Antigen

Synthetic peptide

Reactivity

Human

Host

Rat

Isotype

IgG

Antibody clone number

15G7

Vial size

1 ml

Storage

-20°C

Handling

Aliquot diluted antibody into smaller volumes prior to freezing. Avoid freeze/thaw cycles.

References

Submitted references

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.

Macchi F, Deleersnijder A, Van den Haute C, Munck S, Pottel H, Michiels A, Debyser Z, Gerard M, Baekelandt V
Journal of neuroscience methods 2016 Mar 1;261:117-27

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Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.

Kuzdas-Wood D, Irschick R, Theurl M, Malsch P, Mair N, Mantinger C, Wanschitz J, Klimaschewski L, Poewe W, Stefanova N, Wenning GK
PloS one 2015;10(10):e0136575

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Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.

Paumier KL, Sukoff Rizzo SJ, Berger Z, Chen Y, Gonzales C, Kaftan E, Li L, Lotarski S, Monaghan M, Shen W, Stolyar P, Vasilyev D, Zaleska M, D Hirst W, Dunlop J
PloS one 2013;8(8):e70274

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Intact olfaction in a mouse model of multiple system atrophy.

Krismer F, Wenning GK, Li Y, Poewe W, Stefanova N
PloS one 2013;8(5):e64625

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, Wenning GK, Stefanova N
Glia 2013 Mar;61(3):349-60

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Bladder dysfunction in a transgenic mouse model of multiple system atrophy.

Boudes M, Uvin P, Pinto S, Voets T, Fowler CJ, Wenning GK, De Ridder D, Stefanova N
Movement disorders : official journal of the Movement Disorder Society 2013 Mar;28(3):347-55

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J
Autophagy 2012 May 1;8(5):754-66

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Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH
Neuron 2010 Jan 14;65(1):66-79

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Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia.

Obi T, Nishioka K, Ross OA, Terada T, Yamazaki K, Sugiura A, Takanashi M, Mizoguchi K, Mori H, Mizuno Y, Hattori N
Neurology 2008 Jan 15;70(3):238-41

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Alpha-synuclein overexpression increases cytosolic catecholamine concentration.

Mosharov EV, Staal RG, Bové J, Prou D, Hananiya A, Markov D, Poulsen N, Larsen KE, Moore CM, Troyer MD, Edwards RH, Przedborski S, Sulzer D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 6;26(36):9304-11

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Lipid rafts mediate the synaptic localization of alpha-synuclein.

Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jul 28;24(30):6715-23

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Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P
The Journal of biological chemistry 2001 Nov 16;276(46):42645-57

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Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.

Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Sep 1;20(17):6365-73

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Alpha-synuclein accumulation in a case of neurodegeneration with brain iron accumulation type 1 (NBIA-1, formerly Hallervorden-Spatz syndrome) with widespread cortical and brainstem-type Lewy bodies.

Neumann M, Adler S, Schlüter O, Kremmer E, Benecke R, Kretzschmar HA
Acta neuropathologica 2000 Nov;100(5):568-74