ITGA6

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Description

Integrin subunit alpha 6

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (172427354 - 172506459)

Ensembl ID

ENSG00000091409  (ver. 103.38)

Orthologs

Mouse Itga6: ENSMUSG00000027111

UniProt

P23229

neXtProt

NX_P23229

Human splice variants
Mouse splice variants

Protein structure