CABT-L1657

antibody from Creative Diagnostics

Targeting: WASL N-WASP, NWASP, WASPB

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-L1657

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human N-WASP monoclonal antibody, clone D.538.4

Antibody type

Monoclonal

Description

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

Reactivity

Human, Mouse, Rat, Bovine, Hamster

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

D.538.4

Storage

-20°C