ITGAV

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Description

Integrin subunit alpha V

Tissue specificity

Low tissue specificity

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Cancer-related genes
CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

2 (186590056 - 186680901)

Ensembl ID

ENSG00000138448  (ver. 103.38)

Orthologs

Mouse Itgav: ENSMUSG00000027087

UniProt

P06756

neXtProt

NX_P06756

Human splice variants
Mouse splice variants

Protein structure