SPDEF

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description

SAM pointed domain containing ETS transcription factor

Tissue specificity

Tissue enhanced (prostate, salivary gland)

Subcell location

Nucleoplasm, Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

6 (34537802 - 34556333)

Ensembl ID

ENSG00000124664  (ver. 103.38)

Orthologs

Mouse Spdef: ENSMUSG00000024215

UniProt

O95238

neXtProt

NX_O95238

Human splice variants
Mouse splice variants

Protein structure