PTPRN2

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Description

Protein tyrosine phosphatase receptor type N2

Tissue specificity

Tissue enhanced (brain, pancreas)

Subcell location

Vesicles

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

7 (157539056 - 158587823)

Ensembl ID

ENSG00000155093  (ver. 103.38)

Orthologs

Mouse Ptprn2: ENSMUSG00000056553

UniProt

Q92932

neXtProt

NX_Q92932

Human splice variants
Mouse splice variants

Protein structure