TNFSF8

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description

TNF superfamily member 8

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

9 (114893343 - 114930595)

Ensembl ID

ENSG00000106952  (ver. 103.38)

Orthologs

Mouse Tnfsf8: ENSMUSG00000028362

UniProt

P32971

neXtProt

NX_P32971

Human splice variants
Mouse splice variants

Protein structure