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Immunocytochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Validations
- Flow cytometry [1]
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- Product number
- MAB2770 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal IL-22R alpha 1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human IL-22 R alpha 1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-10, rhIL-22BP or rhIL-20 R alpha is observed.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies.
Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.
Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
The crosstalk between IL-22 signaling and miR-197 in human keratinocytes.
Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.
Interleukin-22 suppresses the growth of A498 renal cell carcinoma cells via regulation of STAT1 pathway.
TH17 cytokines induce human airway smooth muscle cell migration.
El-Zayadi AA, Jones EA, Churchman SM, Baboolal TG, Cuthbert RJ, El-Jawhari JJ, Badawy AM, Alase AA, El-Sherbiny YM, McGonagle D
Rheumatology (Oxford, England) 2017 Mar 1;56(3):488-493
Rheumatology (Oxford, England) 2017 Mar 1;56(3):488-493
Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.
Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA
Mucosal immunology 2017 Jul;10(4):1069-1081
Mucosal immunology 2017 Jul;10(4):1069-1081
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.
Chiu YS, Hsing CH, Li CF, Lee CY, Hsu YH, Chang MS
Scientific reports 2017 Dec 14;7(1):17609
Scientific reports 2017 Dec 14;7(1):17609
Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier RA
Journal of neuroinflammation 2015 Jun 16;12:119
Journal of neuroinflammation 2015 Jun 16;12:119
The crosstalk between IL-22 signaling and miR-197 in human keratinocytes.
Lerman G, Sharon M, Leibowitz-Amit R, Sidi Y, Avni D
PloS one 2014;9(9):e107467
PloS one 2014;9(9):e107467
Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.
Dash R, Bhoopathi P, Das SK, Sarkar S, Emdad L, Dasgupta S, Sarkar D, Fisher PB
Cancer research 2014 Jan 15;74(2):563-74
Cancer research 2014 Jan 15;74(2):563-74
Interleukin-22 suppresses the growth of A498 renal cell carcinoma cells via regulation of STAT1 pathway.
Zhang F, Shang D, Zhang Y, Tian Y
PloS one 2011;6(5):e20382
PloS one 2011;6(5):e20382
TH17 cytokines induce human airway smooth muscle cell migration.
Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH
The Journal of allergy and clinical immunology 2011 Apr;127(4):1046-53.e1-2
The Journal of allergy and clinical immunology 2011 Apr;127(4):1046-53.e1-2
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of IL-22 R alpha 1 in COLO 205 Human Cell Line by Flow Cytometry. COLO 205 human colorectal adenocarcinoma cell line was stained with Mouse Anti-Human IL-22 R alpha 1 Monoclonal Antibody (Catalog # MAB2770, filled histogram) or isotype control antibody (Catalog # MAB002, open histo-gram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).
