TOP2A

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Description

DNA topoisomerase II alpha

Tissue specificity

Tissue enhanced (lymphoid tissue, testis)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (40388525 - 40417896)

Ensembl ID

ENSG00000131747  (ver. 103.38)

Orthologs

Mouse Top2a: ENSMUSG00000020914

UniProt

P11388

neXtProt

NX_P11388

Human splice variants
Mouse splice variants

Protein structure