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- Antibody Data
- Antigen structure
- References [6]
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- Product number
- BAF594 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-21 Biotinylated Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse IL-21 in ELISAs and Western blots. In sandwich immunoassays, less than 0.5% cross-reactivity with recombinant mouse (rm) IL-2, rmIL-4, rmIL-15, and recombinant human IL-21 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Biotin
- Antigen sequence
Q9ES17- Isotype
- IgG
- Vial size
- 50 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf.
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel.
Cytokine-secreting follicular T cells shape the antibody repertoire.
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Hooper KM, Kong W, Ganea D
PloS one 2017;12(6):e0179184
PloS one 2017;12(6):e0179184
Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.
McGuire HM, Walters S, Vogelzang A, Lee CM, Webster KE, Sprent J, Christ D, Grey S, King C
Diabetes 2011 Mar;60(3):867-75
Diabetes 2011 Mar;60(3):867-75
IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE).
Rynda A, Maddaloni M, Ochoa-Repáraz J, Callis G, Pascual DW
PloS one 2010 Jan 14;5(1):e8720
PloS one 2010 Jan 14;5(1):e8720
Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel.
Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2350-9
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2350-9
Cytokine-secreting follicular T cells shape the antibody repertoire.
Reinhardt RL, Liang HE, Locksley RM
Nature immunology 2009 Apr;10(4):385-93
Nature immunology 2009 Apr;10(4):385-93
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
Blood 2008 Jul 15;112(2):362-73
Blood 2008 Jul 15;112(2):362-73
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