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MDH1
Malate dehydrogenase 1This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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| Proteintech Group |  15904-1-AP |
12 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | 15904-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| NovoPro Bioscience Inc. | 112568 |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| GeneTex | GTX40570 |
1 references | Polyclonal |
WB
EL
IP
IHC
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| Wuhan Fine Biotech Co., Ltd. | FNab05073 |
Polyclonal |
WB
EL
ICC
IP
FC
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