XPNPEP2

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

Description

X-prolyl aminopeptidase 2

Tissue specificity

Group enriched (intestine, kidney)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (129738949 - 129769536)

Ensembl ID

ENSG00000122121  (ver. 103.38)

Orthologs

Mouse Xpnpep2: ENSMUSG00000037005

UniProt

O43895

neXtProt

NX_O43895

Human splice variants
Mouse splice variants

Protein structure