NR0B2

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

Description

Nuclear receptor subfamily 0 group B member 2

Tissue specificity

Tissue enhanced (intestine, liver)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Chromosome

1 (26911489 - 26913975)

Ensembl ID

ENSG00000131910  (ver. 103.38)

Orthologs

Mouse Nr0b2: ENSMUSG00000037583

UniProt

Q15466

neXtProt

NX_Q15466

Human splice variants
Mouse splice variants

Protein structure